135 Results for "

Euonymus japonicus Thunb.

" in MedChemExpress (MCE) Product Catalog:
Products (135)

135 Results for "Euonymus japonicus Thunb." in MCE Product Catalog:

32
Chlorogenic acid
Chlorogenic acid
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32 Publications Verification
Cat. No.: HY-N0055
CAS No.: 327-97-9
Synonyms: 3-O-Caffeoylquinic acid; Heriguard; NSC-407296
Category:  

Caprifoliaceae Anti-aging Lonicera japonica Thunb. Plants Endogenous metabolite Infection Human Gut Microbiota Metabolites Microorganisms Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Bacterial Influenza Virus Endogenous Metabolite

Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .
8
Forsythoside B
Forsythoside B
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8 Cited Publications
Cat. No.: HY-N0029
CAS No.: 81525-13-5
Category:  

Oleaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields Inflammation/Immunology

Target:  

TNF Receptor NF-κB

Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
7
Scoparone
Scoparone
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7 Cited Publications
Cat. No.: HY-N0228
CAS No.: 120-08-1
Category:  

Coumarins Phenylpropanoids Plants Compositae Disease Research Fields Artemisia capillaris Thunb. Cancer

Target:  

Others

Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .
6
Ruscogenin
Ruscogenin
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6 Cited Publications
Cat. No.: HY-N0496
CAS No.: 472-11-7
Category:  

Cardiovascular Disease Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Disease Research Fields Steroids

Target:  

NOD-like Receptor (NLR)

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .
3
Cyasterone
Cyasterone
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3 Cited Publications
Cat. No.: HY-N0211
CAS No.: 17086-76-9
Category:  

Crotalaria sessiliflora L. Labiatae Amaranthaceae Plants Disease Research Fields Achyranthes bidentata Cancer Steroids

Target:  

EGFR Apoptosis

Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .
3
Ajugol
Ajugol
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3 Cited Publications
Cat. No.: HY-N0914
CAS No.: 52949-83-4
Category:  

Erythrophleum fordii Oliv. Iridoids Labiatae Terpenoids Other Diseases Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Disease Research Fields

Target:  

Parasite Autophagy Interleukin Related Reactive Oxygen Species (ROS) mTOR

Ajugol is an orally active iridoid glycoside found in the traditional Chinese medicine Leonurus japonicus. Ajugol is an autophagy activator. Ajugol activates TFEB-mediated autophagy and lysosomal biogenesis. Ajugol also has anti-inflammatory effects. Ajugol has great potential in the research of asthma, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis .
2
Wighteone
Wighteone
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2 Cited Publications
Cat. No.: HY-N1073
CAS No.: 51225-30-0
Synonyms: 6-Isopentenylgenistein; Erythrinin B
Category:  

Leguminosae Genista ephedroides DC. Plants Isoflavones

Target:  

Apoptosis EGFR HSP ERK Akt

Wighteone (6-Isopentenylgenistein; Erythrinin B) is a prenylated isoflavone that acts as a HSP90/EGFR L858R/T790M inhibitor and antifungal agent. Wighteone reduces the expression level of HSP90, blocks EGF-induced phosphorylation of EGFR, and thereby inhibits the downstream ERK and AKT signaling pathways. Wighteone induces cell cycle redistribution, inhibits proliferation and triggers apoptosis in cancer cells. Wighteone can be isolated from Erythrina suberosa, and can also be induced to synthesize in Lotus japonicus under specific conditions. Wighteone can be used to study HER2-positive breast cancer, leukemia, non-small cell lung cancer with EGFR L858R/T790M mutation, and fungal infections .
2
Methylophiopogonanone B
Methylophiopogonanone B
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2 Cited Publications
Cat. No.: HY-N2438
CAS No.: 74805-91-7
Category:  

Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields Other Flavonoids

Target:  

Ras Microtubule/Tubulin

Methylophiopogonanone B is a homoisoflavonoid compound. Methylophiopogonanone B can be isolated from O. japonicus root. Methylophiopogonanone B promotes Rho activation and Tubulin depolymerization. Methylophiopogonanone B significantly increases GTP-Rho, but not GTP-Rac or GTP-CDC42. Methylophiopogonanone B induces cell morphological change via melanocyte dendrite retraction and stress fiber formation. Methylophiopogonanone B exhibits strong antioxidant activity. Methylophiopogonanone B can be used in the research of cervical cancer .
1
Obovatol
Obovatol
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1 Cited Publications
Cat. No.: HY-N8259
CAS No.: 83864-78-2
Category:  

Magnoliaceae Other Diseases Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Houpoea obovata (Thunberg) N. H. Xia & C. Y. Wu

Target:  

Others

Obovatol is a biphenyl ether lignan isolated from the leaves of Magnolia obovata Thunb .
1
Ophiopogonin C
Ophiopogonin C
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1 Cited Publications
Cat. No.: HY-N6061
CAS No.: 65586-25-6
Category:  

Ophiopogon japonicus (L. f.) Ker-Gawl. Triterpenes Liliaceae Terpenoids Plants Disease Research Fields Cancer

Target:  

Others

Ophiopogonin C, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin C shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC50s of 19.76 μM and 15.51 μM, respectively .
1
Ophiopogonin D
Ophiopogonin D
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1 Cited Publications
Cat. No.: HY-N0515
CAS No.: 945619-74-9
Category:  

Cardiovascular Disease Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Disease Research Fields Steroids

Target:  

PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK

Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca 2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H2O2-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .
Sec-O-Glucosylhamaudol
Sec-O-Glucosylhamaudol
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Cat. No.: HY-N0398
CAS No.: 80681-44-3
Category:  

Flavonoids Flavones Carpesium cernuum L. Plants Umbelliferae

Target:  

Opioid Receptor

Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect .
Pectolyase Y-23, A. japonicus
Pectolyase Y-23, A. japonicus
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Cat. No.: HY-E70396
CAS No.: 9033-35-6
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

Pectolyase Y-23, A. japonicus is an enzyme derived from Aspergillus japonicas. Pectolyase Y-23, A. japonicus can be used in combination with cellulase to isolate bioactive protoplasts .
3-O-Caffeoylquinic acid methyl ester
3-O-Caffeoylquinic acid methyl ester
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Cat. No.: HY-N4168
CAS No.: 123483-19-2
Category:  

other families Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

HBV

3-O-Caffeoylquinic acid methyl ester is a monocaffeoylquinic acid derivative and phenolic acid component, which can be found in the whole plant of Pyrrosia calvata (Backer) Ching and the flower buds of Lonicera japonica Thunb .
Pseudoginsenoside RT5
Pseudoginsenoside RT5
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Cat. No.: HY-N0542
CAS No.: 98474-78-3
Category:  

Triterpenes Panax quinquefolium Terpenoids Plants Disease Research Fields Araliaceae Cancer

Target:  

Bacterial

Pseudoginsenoside RT5 is an orally active ocotillol-type ginsenoside and Antibacterial agent. Pseudoginsenoside RT5 can be isolated from American ginseng, transgenic American ginseng crown gall tumors and Panax japonicus. Pseudoginsenoside RT5 exerts cardioprotective effects against myocardial injury, and also possesses antibacterial and antitumor activities. Pseudoginsenoside RT5 can be used in research related to Alzheimer's disease, myocardial injury, tumors and bacterial infections .
6-Aldehydoisoophiopogonone A
6-Aldehydoisoophiopogonone A
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Cat. No.: HY-N7942
CAS No.: 112500-90-0
Category:  

Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Flavonoids Plants Isoflavones

Target:  

Others

6-Aldehydoisoophiopogonone A is a homoisoflavonoid that can be isolated from Ophiopogon japonicus .
Methylophiopogonone A
Methylophiopogonone A
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Cat. No.: HY-N2441
CAS No.: 74805-90-6
Category:  

Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Flavonoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Other Flavonoids

Target:  

NO Synthase Collagen p38 MAPK

Methylophiopogonone A is a homoisoflavonoid compound found in the tuberous roots of Ophiopogon japonicus. Methylophiopogonone A inhibits lipopolysaccharide-induced NO production in mouse microglia with an IC50 of 19.2 μM. Methylophiopogonone A blocks the proliferation of LX-2 hepatic stellate cells and downregulates TGF-β1-induced expressions of type I collagen and α-SMA. Methylophiopogonone A blocks RELA/EGFR-mediated hepatic stellate cell activation, inhibits the MAPK12 pathway to reduce extracellular matrix accumulation, and simultaneously suppresses inflammatory signal transduction. Methylophiopogonone A can be used in studies related to chronic hepatitis B-associated hepatic fibrosis and neuroinflammation .
Araliadiol
Araliadiol
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Cat. No.: HY-N2887
CAS No.: 1354638-93-9
Category:  

Natural Products Aralia cordata Thunb. Plants Disease Research Fields Araliaceae Cancer

Target:  

Others

Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 μg/mL .
Allocryptopine
Allocryptopine
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Cat. No.: HY-N1933
CAS No.: 485-91-6
Category:  

Cardiovascular Disease Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Isoquinoline Alkaloids Papaveraceae

Target:  

Potassium Channel

Allocryptopine, a derivative of tetrahydropalmatine, is extracted from Macleaya cordata (Thunb.) Pers. Papaveraceae. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current .
14-Hydroxy sprengerinin C
14-Hydroxy sprengerinin C
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Cat. No.: HY-N3505
CAS No.: 1111088-89-1
Category:  

Dipsacaceae Other Diseases Dipsacus asper Wall. Plants Disease Research Fields Steroids

Target:  

Others

14-Hydroxy sprengerinin C is a steroidal compound found in Ophiopogon japonicus.
Assay Types